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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN6 All Species: 22.73
Human Site: S553 Identified Species: 45.45
UniProt: P29350 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P29350 NP_002822.2 595 67561 S553 K N A H A K A S R T S S K H K
Chimpanzee Pan troglodytes XP_001163468 596 67703 S554 K N A H A K A S R T S S K H K
Rhesus Macaque Macaca mulatta XP_001110915 597 67615 S555 K N A H A K A S R T S S K H K
Dog Lupus familis XP_543844 595 67669 S553 K N A H A K A S R T S S K H K
Cat Felis silvestris
Mouse Mus musculus P29351 595 67540 S553 R S A H A K A S R T S S K H K
Rat Rattus norvegicus P81718 613 69560 S555 R S A H A K A S R T S S K H K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519010 556 61792 N515 L S F L D Q I N Q R Q E S L P
Chicken Gallus gallus Q90687 593 67964 D551 N I K Y S L S D Q T S G D Q S
Frog Xenopus laevis NP_001085766 594 68095 E551 N I Q Y S A G E R A R T K A Q
Zebra Danio Brachydanio rerio NP_956254 589 66986 K547 S I Q S K H P K A S R K A S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P29349 845 92957 P683 G N D S Q R S P L P P A I S S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784121 533 60826 P492 G S T P I L S P A I L N E D K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.9 97.8 96.1 N.A. 94.4 91 N.A. 68 54.2 58.3 64.7 N.A. 33.8 N.A. N.A. 43.3
Protein Similarity: 100 98.8 98.4 97.9 N.A. 98.1 94.9 N.A. 72.9 70.7 72 78.4 N.A. 46.9 N.A. N.A. 60.8
P-Site Identity: 100 100 100 100 N.A. 86.6 86.6 N.A. 0 13.3 13.3 0 N.A. 6.6 N.A. N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 26.6 40 40 6.6 N.A. 26.6 N.A. N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 50 0 50 9 50 0 17 9 0 9 9 9 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 9 0 9 0 0 9 0 0 0 0 9 9 0 % D
% Glu: 0 0 0 0 0 0 0 9 0 0 0 9 9 0 0 % E
% Phe: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 17 0 0 0 0 0 9 0 0 0 0 9 0 0 0 % G
% His: 0 0 0 50 0 9 0 0 0 0 0 0 0 50 0 % H
% Ile: 0 25 0 0 9 0 9 0 0 9 0 0 9 0 0 % I
% Lys: 34 0 9 0 9 50 0 9 0 0 0 9 59 0 59 % K
% Leu: 9 0 0 9 0 17 0 0 9 0 9 0 0 9 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 17 42 0 0 0 0 0 9 0 0 0 9 0 0 0 % N
% Pro: 0 0 0 9 0 0 9 17 0 9 9 0 0 0 9 % P
% Gln: 0 0 17 0 9 9 0 0 17 0 9 0 0 9 9 % Q
% Arg: 17 0 0 0 0 9 0 0 59 9 17 0 0 0 0 % R
% Ser: 9 34 0 17 17 0 25 50 0 9 59 50 9 17 25 % S
% Thr: 0 0 9 0 0 0 0 0 0 59 0 9 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 17 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _